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About the collection

The Disease Collection Cell Catalog is a growing compilation of cell lines that carry mutations in genes known to cause disease. These cell lines were created by introducing a point mutation in one of the fluorescently tagged WTC-11 clonal lines from the Allen Cell Collection.

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Disease models available in our collection

Laminopathy

Cell Collection ID

AICS-0119

Obtain Collection

Skeletal Myopathy

Cell Collection ID

AICS-0113

Obtain Collection

All cell lines were originally generated using the WTC-11 hiPS cell line as the parental cell line. Access whole genome sequence data (100X coverage) for the WTC-11 line on the Genomics page. The donor of the WTC line has consented to the sharing of this data.

Acknowledgements

These cell lines were generated at the Allen Institute for Cell Science and released to a group of collaborators to perform preliminary studies. We would like to thank the following:

Daniel Berstein, MD, Stanford University
Abigail Buchwalter, PhD, University of California, San Francisco
Francis Collins, MD, PhD, NIH
Michael Erdos, PhD, NIH
Soah Lee, PhD, Sungkyunkwan University
David Mack, PhD, University of Washington
Beth Pruitt, PhD, University of California, Santa Barbara
Mike Regnier, PhD, University of Washington
James Spudich, PhD, Stanford University
Sean Wu, MD, PhD, Stanford School of Medicine
Zhengmei Xiong, PhD, NIH

The Allen Institute for Cell Science also acknowledges the following people for their expertise and support:

Bruce R. Conklin, Gladstone Institute and University of California, San Francisco
Charles E. Murray, University of Washington
William C. Skarnes, Wellcome Trust Sanger Institute
David Drubin, University of California, Berkley

Funding

We wish to thank Allen Institute founders, Jody Allen & Paul G. Allen, for their vision, encouragement, and support.